Wednesday, 13 December 2017

Epidemiology and Asthma

Asthma is an interminable malady including the aviation routes in the lungs. These aviation routes, or bronchial tubes, enable air to come all through the lungs.If you have asthma your aviation routes are constantly aggravated. They turn out to be much more swollen and the muscles around the aviation routes can fix when something triggers your side effects. This makes it troublesome for air to move all through the lungs, causing manifestations, for example, hacking, wheezing, shortness of breath as well as chest tightness.For numerous asthma sufferers, timing of these side effects is firmly identified with physical action. What's more, some generally sound individuals can create asthma indications just when working out. This is called work out initiated bronchoconstriction (EIB), or exercise-incited asthma (EIA). Remaining dynamic is an imperative approach to remain solid, so asthma shouldn't keep you on the sidelines. Your doctor can build up an administration intend to monitor your manifestations previously, amid and after physical activity.People with a family history of hypersensitivities or asthma are more inclined to creating asthma. Many individuals with asthma likewise have hypersensitivities. This is called unfavorably susceptible asthma.
Allergic asthma
This type occurs when an allergy sets off an asthma flare up. Mold, roaches, pollens and pet dander are common allergies but the list can be endless.  Food sensitivities may also play a role. “I think food can have a lot to do with it when it comes to the toxic burden that you put in your body,” says Pescatore.
Pescatore explains there is a strong correlation between casein, the protein in milk and cheese that may trigger asthma. Gluten, yeast and sugar may also be culprits. “I always look for the non toxic approach first so I have people do food elimination diets and a food sensitivity test,” says Pescatore.
“Most of the time we treat this type by finding out what patient’s are allergic to first, so they know what they should avoid,” says Lee. Patients may be prescribed inhaled corticosteroids depending on the severity of their asthma.
Individuals may likewise have asthma not activated by hypersensitivities. Generally an upper respiratory disease (cool, influenza, and rhinovirus) sets off their asthma. When frosty or influenza side effects show up patients are commonly endorsed a short course of breathed in corticosteroids for 10-14 days.
Pescatore has patients wipe out known hypersensitivities, any sustenance sensitivities and eat a perfect eating routine of low glycemic file protein, natural products, vegetables and nuts to check whether this has any kind of effect. "Anyone who has asthma has a provocative condition," says Pescatore. "In the event that you diminish irritation in the body, you diminish your body's have to 'carry on' in a manner of speaking. At the point when there is less aggravation around there is less requirement for your bronchials to tighten and your pole cells to initiate and everything that happen amid an asthma assault."
This type is triggered by aspirin. Patients may have nasal polyps, rhinitis, sneezing and a runny nose, and a history of aspirin sensitivity. When they take aspirin, they develop sneezing and a stuffy nose, which leads to wheezing and difficulty breathing. “If this type of asthma is severe enough, we actually recommend aspirin desensitization. The body is desensitized with incremental doses of aspirin usually done in a hospital setting,” says Lee. Once people tolerate the full dose of aspirin they take a daily maintenance dose, which has been shown to help with polyps, allergies and asthma.
Exercise induced asthma
A worn out sprinter for these asthmatics, any sort of physical effort or games prompts hacking, trouble breathing and chest snugness that enhances when they stop the effort. Average treatment is a breathed in broncodilator medicine to open their aviation route taken around fifteen minutes previously work out.
"There are different investigations that say taking 2000 mg of vitamin C before exercise can assuage practice initiated asthma," says Pescatore. A few people likewise have frosty climate instigated asthma. Icy air can be a lung aggravation quite recently like scent or tobacco smoke.
Hack variation is asthma that is described by a dry hacking hack. It can happen while conscious or snoozing and influence the two grown-ups and kids. Patients more often than not react well to breathed in corticosteroids. Vitamin D has additionally been appeared to enhance asthma. Studies appear there is less rate of asthma in the south, which might be identified with individuals having less sun introduction and lower vitamin D levels in northern atmospheres.
Occupational asthma
Word related asthma happens when something at work sets off an asthma assault. Aggravation instigated asthma is more often than not from smoke or breathed in aggravations like chlorine. It's not identified with a sensitivity; the aggravation is breathed in and triggers an assault.
In occupations that arrangement with chemicals like paint or lab creatures like rats or mice, patients may likewise be adversely affected by their trigger. They should discover precisely what sets off their manifestations and endeavor to keep away from it. On the off chance that you can't make tracks in an opposite direction from your trigger, you may need to utilize a corticosteroid inhaler to ease indications. Pescatore additionally enjoys vitamin A, which has been appeared to help dispose of the bodily fluid in the respiratory tract, which can be an aggravation.

Past Conference report of Epidemiology 2017

We would like to thank all of our wonderful keynotes, speakers, conference attendees, students, associations, media partners, exhibitors and guests for making Epidemiology 2017 a successful event.
Conference Series LLC hosted the 6th World Congress on Epidemiology and Public Health during October 23-25, 2017 at Hotel Holiday Inn Paris, France with the theme “Epidemiological and health transitions in the 21st century”. Benevolent response and active participation was received from the Editorial Board Members of supporting International Journals as well as from the leading academic scientists, researchers, research scholars, students and leaders from the fields of Epidemiology and Public Health , who made this event successful.
The conference was marked by the attendance of young and brilliant researchers, business delegates and talented student communities representing more than 48 countries, who have driven this event into the path of success. The conference highlighted through various sessions on current retroviral research.
Epidemiology 2017 witnessed an amalgamation of peerless speakers who enlightened the crowd with their knowledge and confabulated on various new-fangled topics related to the fields of Epidemiology and Public Health.
The meeting was carried out through various sessions, in which the discussions were held on the following major scientific tracks:
Ø  Epidemiology and Public Health
Ø  Epidemiology and Surveillance
Ø  Epidemiology and Antibiotic Resistance
Ø  Epidemiology and Medicine
Ø  Epidemiology and Infectious Disease
Ø  Epidemiology and Chronic Diseases
Ø  Epidemiology and Disease Outbreak
 The conference was embarked with an opening ceremony followed by a series of lectures delivered by both Honorable Guests and members of the Keynote forum. The adepts who promulgated the theme with their exquisite talk were;
Ø  Ray M Merrill, Brigham Young University, USA
Ø  Jean Caron, McGill University, Canada
Ø  Wolfgang Seger, Health Advisory Board, Germany
Ø  Henry Völzke, University Medicine Greifswald, Germany
Ø  Carolina M Borges, The College of New Jersey, USA
Ø  Cristina Stasi, Regional Health Agency of Tuscany, Italy
Ø  Flores, R. A, National University of Santiago del Estero, Argentina
The event enlightened various arenas of Health care, with plenary lectures from the speakers of various universities and organizations like
Edward S Peters, Louisiana State University Health Sciences Center, USA
Mayvor Ström, Primary Health Care, Sweden
Alma Sorberg Wallin, Karolinska Institute, Sweden
Sarah Donovan, University of Otago, New Zealand
Susan C Hu, National Cheng Kung University, Taiwan
Anne Sophie Mariet, Burgundy Franche-Comte University, France
Tea Skaaby, Research Centre for Prevention and Health, Denmark
Jeonghoon Kim, Seoul Medical Center, South Korea
Chrissy Bishop,University of Bradford, UK
Isaac M Danat, University of Wolverhampton,UK
We are also obliged to various delegate experts, company representatives and other eminent personalities who supported the conference by facilitating active discussion forums. We would like to  thank the Organizing Committee Members for their gracious presence, support, and assistance towards the success of Epidemiology 2017.

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Tuesday, 6 December 2016

Clonal hematopoiesis may help predict cancer patients at risk for fatal form of leukemia

Clonal hematopoiesis may help predict cancer patients at risk for fatal form of leukemia: Patients successfully treated for breast, colon and other cancers can go on to develop an often-fatal form of leukemia, sometimes years after completion of treatment, due to a genetic mutation leading to secondary malignancies known as therapy-related myeloid neoplasms (t-MNs).
Published on December 4, 2016 at 11:12 PM · No Comments
Patients successfully treated for breast, colon and other cancers can go on to develop an often-fatal form of leukemia, sometimes years after completion of treatment, due to a genetic mutation leading to secondary malignancies known as therapy-related myeloid neoplasms (t-MNs).
A study conducted by researchers at The University of Texas MD Anderson Cancer Center revealed pre-leukemic mutations, called clonal hematopoiesis, may predict whether patients develop t-MNs. Clonal hematopoiesis appears to function as a biomarker for patients who develop t-MNs, a leukemia recognized for its extremely poor prognosis. The study findings were published today in The Lancet Oncology and presented at the annual meeting of the American Society of Hematology in San Diego.
"Therapy-related myeloid neoplasms occur in about 5 percent of cancer patients who were treated with chemotherapy and/or radiation therapy," said Andy Futreal, Ph.D., chair ad interim of Genomic Medicine. "In most cases, it is fatal, and currently there is no way to predict who is at risk or prevent it.
Being able to detect t-MNs earlier is crucial given that the disease usually occurs three to eight years following chemotherapy and/or radiation therapy.
"T-MNs are a problem that needs urgent attention," said Koichi Takashi, M.D., assistant professor of Leukemia and Genomic Medicine and a co-author on the Lancet Oncology paper. "Since many cancer patients are now living longer, t-MNs are an increasing concern for many cancer survivors."
Futreal's team studied 14 patients with t-MNs and found traces of pre-leukemic mutations or clonal hematopoiesis in 10. To determine if pre-leukemic mutations could reliably predict whether the patients would develop leukemia, the researchers compared prevalence of pre-leukemic mutations in the 14 patients with 54 patients who did not develop t-MNs after therapy.
"We found that prevalence of pre-leukemic mutations was significantly higher in patients who developed t-MNs (71 percent) versus those who did not (26 percent)," said Futreal. "We also validated these findings in a separate cohort of patients. Based on these findings, we believe pre-leukemic mutations may function as a new biomarker that would predict t-MNs development."
In the sample of 14 patients with t-MNs, the team looked at samples of bone marrow at the time of t-MNs development and blood samples obtained at the time of their primary cancer diagnosis.
"We found genetic mutations that are present in t-MNs leukemia samples actually could be found in blood samples obtained at the time of their original cancer diagnosis," said Takahashi. "Based on this finding, we believe the data suggest potential approaches of screening for clonal hematopoiesis in cancer patients that may identify patients at risk of developing t-MNs, although further studies are needed."
University of Texas M. D. Anderson Cancer Center

Monday, 5 December 2016

LOS ANGELESOct. 23, 2016 /PRNewswire/ -- International Open Access Week - a global event in conjunction with this year's Open Access Week Advisory Committee, entering in its 9th international year. The event is going to be celebrated from October 24 to 30, 2016.The announced theme for this year is "Open in Action."
International Open Access Week is an opportunity for the academic and research community to learn about the potential benefits of Open Access and to share the information with their colleagues. Therefore, "Open Access Week" celebration will help to inspire huge participation in order to make Open Access a new norm in the research and scholarship.
"Open Access" has the power to transform the research and scientific information dissemination with the free, immediate, online access of the results along with the right to use and re-use the published results as needed. Numerous Research funding agencies, academic institutions, researchers and scientists, teachers, students, and general public are supporting the movement of Open Access which is gaining additional momentum every year.
This Open Access Week provides an opportunity for every members of the community to take action in keeping this momentum moving forward. So Get Enrolled. Taking part in Open Access Week can be a simple way to become a part of the future societal benefits.
OMICS International has been a follower of Open Access system since its inception. The lead taken by OMICS International in this regard has been a great success and we would like to ensure the continuation of the same.
With the following present Open Access week theme of "Open in Action" we request our distinguished Editors, Authors and reviewers to participate in this campaign and share their knowledge and experience with us. We request all the associated eminent personalities send us their suggestions, comments at
About OMICS International
OMICS Group with its 2000+ employees has been supported by 50000+ well-qualified scientists as editorial board members who serve on voluntary basis to disseminate healthcare and scientific information open access, and year on year this support is increasing progressively with which OMICS Group is able to grow from 10 peer reviewed journals in 2009 to 700 peer reviewed journals by 2016, and readers base increased to 30 million.
SOURCE OMICS International

Tuesday, 22 November 2016

Avoiding Endocrine Disruptors Drops Diabetes Risk: Study

Based on epidemiological data, researchers estimate that reducing exposures to certain environmental chemicals could drop people’s chances of developing the disease.
By  | October 27, 2016
Some environmental chemicals, such as plastics additives and certain pesticides, act as endocrine disruptors and can perturb animals’ metabolisms in the lab. Epidemiological studies have also linked human exposures to these substances with an increased risk for developing diabetes. A study published today (October 27) in the Journal of Epidemiology & Community Health estimates that cutting exposures by 25 percent could reduce the prevalence of diabetes by 13 percent among the elderly in Sweden.
“Extrapolating to Europe, 152,481 cases of diabetes in Europe and €4.51 billion/year in associated costs could be prevented,” the authors, led by Leonardo Trasande at New York University School of Medicine, wrote in their report.
Trasande and his colleagues used data from a study of about 1,000 elderly Swedes whose blood was sampled to estimate their exposures to certain chemicals. Specifically, the researchers looked at four so-called “diabetogens”: two phthalates (plastics additives), a polychlorinated biphenyl (PCB), and PFNA, a surface-coating compound.
From the data they calculated a reduction in diabetes risk if exposure to each compound dropped by 25 percent. Although their estimates found reducing exposure to any one chemical didn’t make a difference, cutting back on all four together resulted in a 13 percent drop in diabetes prevalence. In comparison, reducing the body mass index of the population led to an estimated 40 percent reduction in diabetes prevalence.
In a study published earlier this month in The Lancet, Trasande and his collaborators estimated that the cost associated with Americans’ exposure to endocrine-disrupting chemicals—in healthcare expenses, intellectual disabilities, and lost days of work—is about $340 billion per year.
“Our research adds to the growing evidence on the tremendous economic as well as human health costs of endocrine-disrupting chemicals,” Trasande said in a press release.
One limitation of the paper published in The Lancet, according to Joseph Perrone, the chief science officer for the Center for Accountability in Science, is that the study “doesn't distinguish between endocrine action and endocrine disruption,” he told CNN. “This is an important distinction because activity does not by itself cause harm.”

Monday, 21 November 2016

ESCMID experts raise awareness for optimal use of antibiotics to combat AMR

Published on November 21, 2016 at 4:42 AM ·
On 18 November ESCMID is organizing a number of activities to promote prudent use of antibiotics in Europe. These include events at healthcare institutions and public campaigns on antimicrobial resistance (AMR), surveillance and antibiotic stewardship programmes in Moldova, Turkey, Spain, Cyprus and the Netherlands.
Prof. Jesús Rodríguez-Baño, ESCMID President-elect and Secretary General:
Antimicrobial resistance is a global threat that has been at the core of ESCMID’s activities – at our study groups, committees, courses and conferences over the past years. Our experts have been committed to developing hands-on solutions by supporting and promoting research and training to tackle the problem around the world. The society offers professional training and programmes on antimicrobial stewardship, infection control and surveillance resistance. It develops medical guidelines, policies for antimicrobial use, and initiatives to promote novel diagnostics, vaccines and therapies.
The society has undertaken a number of initiatives to effectively fight the growing problem. Only in September ESCMID together with the American Society for Microbiology organized an international conference on drug development to meet the AMR challenge. Drawing from the outcomes of the conference ESCMID plans to publish a position paper on its strategy and role in the fight against AMR.
AMR will once again be one of the main topics at ECCMID, the world’s largest congress in infectious diseases and clinical microbiology usually gathering some 12,000 specialists, from 22 – 25 April 2017 in Vienna. A book on antimicrobial stewardship produced by ESCMID and ESCMID Study Group for Antibiotic Policies (ESGAP) is due for publication in April 2017. The book has been developed by key experts in the field as a practical ‘hands-on’ book to help antimicrobial stewardship team members design and implement their programme, in all healthcare settings. It can also be used as an undergraduate and postgraduate training tool for infectious diseases specialists, microbiologists, pharmacists, nurses, and any other professionals involved in antimicrobial stewardship.
ESCMID has been supporting governments and international organizations to develop and implement policies on evidence-based prevention, infection control, surveillance of resistance, antimicrobial stewardship and sanitation to guarantee an optimal use of antimicrobial medicines. The society welcomes the fact that the topic moved to the top of the global agenda in September when the United Nations General Assembly called a high-level meeting to address a problem that is projected to cause up to 10 million annual deaths by 2050.
Concrete efforts of ESCMID over the past years include the European Committee on Antimicrobial Susceptibility Testing (EUCAST), jointly organized by ESCMID and the ECDC, which defines so-called breakpoints required to define optimal dosing of antibiotics and thus distinguish between therapeutic success and failure. Recently EUCAST completed a review of breakpoints or fluoroquinolone and carbapenem, two of the most important groups of antibiotics, and defined breakpoints and susceptibility methods for new agents and additional bacterial species. Its experts also conducted a study that showed that phenotypic antimicrobial susceptibility testing (PAST) is a better predictor of susceptibility, while whole genome sequencing (WGS) is more useful for characterizing resistance genes and mechanisms.
One of the more recent initiatives include European Committee on Infection Control (EUCIC), which was created in 2014 to support the implementation of infection control and preventive (ICPM) measures to reduce the burden of healthcare-associated infections. Among many on going projects, EUCIC is currently involved in the PERCEPT-R project, which aims to investigate the perceptions of infection control specialists regarding AMR and infection prevention and control in different countries, and the role played by the cultural, contextual and behavioural aspect on the prevention of AMR. In order to contribute to the harmonisation of ICPM and standardisation of procedures, EUCIC is working on developing new educational tools that could provide a new generation of infection control specialists with a global European perspective and competence. Increasing burden of infectious diseases, epidemiology as well as demographic changes and mass migration are overwhelming facts that no nation alone will be able to overcome.
EUCIC together with major stakeholders and the national representatives in the EUCIC advisory board is currently developing a European training programme for infection control in healthcare settings.
AMR will continue to be a focus for ESCMID education
ESCMID has offered courses relevant to antimicrobial stewardship and drug-resistant infections this year, including:
  • 18-19 January (Cape Town, South Africa): Diagnosis and management of drug-resistant TB.
  • 7-8 April (Ijmuiden Aan Zee, Netherlands): Antimicrobial stewardship.
  • 29 May - 1 June 2016 (Groningen, Netherlands): Infection Prevention and Control: Let's Get Practical!, ESCMID Postgraduate Technical Workshop.
  • 20-23 September (Bochum, Germany): Antimicrobial susceptibility testing and surveillance from laboratory to clinic.
Further courses are planned for the coming 12 months, including:
  • Hospital-Acquired Infections: Understanding the Magnitude and Needed Interventions, 23 – 24 March in Muscat, Oman
  • Antimicrobial Resistance Across Europe and the Far East: Issues and Solutions, 26 -27 May 2017, Taipei, Taiwan
  • Advanced Technical Workshop: Infection and Resistance Prevention in the Regional Healthcare Network, 31 May – 1 June 2017, Groningen, Netherlands
  • Emerging Antibiotic Resistance in Gram-Negative Bacteria: Problems and Solutions, 14 - 15 September 2017, Fribourg, Switzerland
  • Antimicrobial Stewardship: Principles and Practice, 4 - 6 October 2017, Istanbul, Turkey